Friday, April 16, 2010

Renal Complications Common with Pandemic Flu

According to an article published in Renal & Urology News, acute kidney injury (AKI), acute renal failure (ARF), and the need for dialysis are common complications in critically ill patients with 2009 H1N1, and are associated with an increased death risk, according to Canadian researchers.

Manish M. Sood, MD, and colleagues at the University of Manitoba in Winnepeg, prospectively studied 50 patients with 2009 H1N1 admitted to one of seven ICUs in Manitoba. Subjects had a mean age of 35.5 years and 72% were women.

AKI developed in 66.7% of the patients for whom this complication could be determined. Eleven patients (22%) required dialysis; of these, 10 recovered. Eight patients (16%) died. AKI and kidney failure were associated with a 5.7 and 11 times increased risk of death. The need for dialysis was associated with a 21% increased risk.

In addition, patients requiring dialysis had a significantly increased ICU stay compared with those not requiring dialysis (mean 33.3 vs. 19.3 days).

The researchers concluded that critically ill patients with H1N1 infection suffer a high rate of kidney injury, kidney failure, and the need for dialytic therapies. Kidney injury was also strongly associated with mortality.

The researchers also stress that longer ICU stay for patients needing dialysis could significantly stress hospital resources in the event of a future outbreak.

Source: Renal & Urology News

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